Introduction: Gonadotroph adenomas are generally nonfunctioning. Hypersecretion\nof gonadotropins by gonadotroph adenomas rarely induced hypersecretion\nof testosterone. We report a case of functioning gonadotroph adenoma\nwith secondary hypersecretion of testosterone. Medical Observation:\nA 25-year-old patient who having had a progressive and bilateral loss of visual\nacuity for two years. The ophtalmologistâ??s examination concluded to bitemporal\nhemianopia. He had no other clinical manifestations of hyper or hypo\nhormonal secretion. The brain scan has revealed an intrasellar mass with suprasellar\ndevelopment that represses the optic chiasma and the carotids. The\nassessment carried out revealed an increase in FSH, LH and testosterone. The\ndiagnosis of a functioning gonadotroph macroadenoma with secondary hypersecretion\nof testosterone was retained. Surgical excision of the adenoma was\nperformed. Anatomo-pathological examination concluded to a pituitary adenoma.\nThe patient showed an improvement in the right visual acuity and developed\nan adrenal corticotropic insufficiency substituted by hydrocortisone 20\nmg per day. The postoperative hormonal profile revealed a normalization of\nFSH and testosterone. Conclusion: Functioning gonadotroph adenoma with\nsecondary hypersecretion of testosterone is rare. The first-line treatment is\nsurgical and allows an improvement of the cerebral tumor syndrome and the\nrestoration of the gonadotropic function.
Loading....